17-Hydroxyprogesterone

17-Hydroxyprogesterone - 17-Hydroxyprogesterone is elevated in patients with Congenital Adrenal Hyperplasia (CAH). CAH is a group of autosomal recessive diseases characterized by a deficiency of cortisol and an excess of ACTH concentration. 17-Hydroxyprogesterone is also useful in monitoring cortisol replacement therapy and in evaluating infertility and adrenal and ovarian neoplasms.

Hydroxyprogesterone, 17-OHP is an endogenous progestogen steroid hormone made by the adrenal glands, two glands located on top of the kidneys,is related to progesterone.
This test can be done as a routine if a female has increased growth of facial and body hair or a newborn`s normal screening when a baby`s sex is not clear (ambiguous genitalia) or for any other symptoms which is related to elevated male sex hormones. This test can be done to monitor patients undergoing CAH treatment.
This test measures the amount of 17-hydroxyprogesterone in the blood.

Reference Range(s)
Adult Males
18-30 years 32-307 ng/dL
31-40 years 42-196 ng/dL
41-50 years 33-195 ng/dL
51-60 years 37-129 ng/dL
Adult Females
Pre-Menopausal Mid Follicular 23-102 ng/dL
Pre-Menopausal Surge 67-349 ng/dL
Pre-Menopausal Mid Luteal 139-431 ng/dL
Postmenopausal Phase =45 ng/dLPregnancy
First Trimester 78-457 ng/dL
Second Trimester 90-357 ng/dL
Third Trimester 144-578 ng/dL
Pediatric
Cord Blood** 1000-3000 ng/dL
Premature Infants** (31-35 weeks) =405 ng/dL
Term Infants (12 hrs)** 460 ng/dL
Values decline gradually to prepubertal levels

Male and Female
30 days Not established
1-11 months =147 ng/dL
1 year =139 ng/dL
2 years =134 ng/dL
3 years =131 ng/dL
4 years =131 ng/dL
5 years =133 ng/dL
6 years =137 ng/dL
7 years =145 ng/dL
8 years =154 ng/dL
9 years =166 ng/dL
10 years =180 ng/dL
11 years =196 ng/dL
12 years =213 ng/dL
13 years =233 ng/dL
14 years =254 ng/dL
15 years 19-276 ng/dL
16 years 23-300 ng/dL
17 years 26-325 ng/dL
Tanner Stages**
II-III Males 12-130 ng/dL
II-III Females 18-220 ng/dL
IV-V Males 51-190 ng/dL
IV-V Females 36-200 ng/dL