Description
Estrone is a form of the hormone estrogen. The estrone test is ordered to evaluate postmenopausal vaginal bleeding due to peripheral conversion of androgenic steroids as well as to guide female hormone replacemnt therapy. Increased estrone levels may be associated with increased levels of circulating androgens and their subsequent peripheral conversion.Estrone is primarily derived from metabolism of androstenedione in peripheral tissues, especially adipose tissues. Individuals with obesity have increased conversion of androstenedione to Estrone leading to higher concentrations. In addition, an increase in the ratio of Estrone to Estradiol may be useful in assessing menopause in women.Estrone, also known as E1, may be measured in women who have gone through menopause to determine their estrogen levels. E1, is the main female hormone made by women after menopause. Menopause is a time in a woman`s life when her menstrual periods have stopped and she can`t become pregnant anymore. It usually starts when a woman is around 50 years old.It also may be measured in men or women who might have cancer of the ovaries, testicles, or adrenal glands. Estrone is naturally produced by the ovaries in women and the fat tissue linings in children, men, and postmenopausal women.
Estrone is a form of Estrogen.It is the major form that is produced following menopause. Adipose tissue (fat) is commonly where estrone is produced. This test is used to evaluate postmenopausal vaginal bleeding due to peripheral conversion of androgenic steroids. Increased estrone levels may be associated with increased levels of circulating androgens and their subsequent peripheral conversion.Estrone (E1) is directly converted from androstenedione (from the adrenal gland) or indirectly from other androgens. E1 can also be produced by the ovaries and placenta, testicles, and adipose (fat) tissues. E2 and E1 can be converted into each other as needed. E1 is the primary estrogen in men and in post-menopausal women.E1 also rises during pregnancy, increasing as much as 10-fold between weeks 24 and 40. After delivery, E1 falls and E3 again becomes essentially undetectable.
Estrone (E1) testing in girls and women may be ordered when:
A girl`s sex organs develop earlier or later than normally expected
A woman has symptoms such as abnormal vaginal bleeding after menopause or abnormal or lack of menstrual cycles
A woman is experiencing infertility; a series of estradiol measurements over the course of a woman`s menstrual cycle may be done to monitor follicle development prior to in vitro fertilization techniques (timed with a surge in estradiol).
A woman is having symptoms of menopause, including hot flashes, night sweats, insomnia, and/or irregular or lack of menstrual periods
A menopausal woman is taking hormone replacement therapy; her health practitioner may periodically order estrone levels to monitor treatment.
This blood test does not require fasting in preparation. Results are delivered within two to three days of taking the test. Estrone is the least abundant of the three forms of estrogen and is relevant to health and disease because it is considered the stronger acting estrogen. It is the main form of estrogen in postmenopausal women. Any type of contraceptives that contain hormones will invalidate hormone results.
The estrone serum test measure and monitor estrogen levels and help explain abnormal menstrual cycles, infertility symptoms of menopause, abnormal or heavy bleeding, infertility, or any other hormonal alterations. This blood test is also used to check for fetal-placental status during early stages of pregnancy and to evaluate feminization (the presence of female-like characteristics in males). An E1 blood test can help evaluate postmenopausal vaginal bleeding due to peripheral conversion of androgenic steroids. Additionally, increased estrone levels may be associated with increased levels of circulating androgens and their subsequent peripheral conversion.Estrone levels may be elevated in patients with polycystic ovarian syndrome and endometriosis. Tests may be used to aid in the diagnosis of an ovarian tumor, Turner syndrome, and hypopituitarism.
