Description
IGF-1, LC/MS - Insulin-like Growth Factor 1 (IGF-1, or Somatomedin C), a protein involved in stimulating somatic growth, is regulated principally by Growth Hormone (GH) and nutritional intake. IGF-1 is transported in serum by several proteins; this helps maintain relatively high IGF-1 plasma levels and minimizes fluctuations in serum IGF-1 concentrations.
Measuring IGF-1 is useful in several growth-related disorders. Dwarfism caused by deficiency of growth hormone (Hypopituitarism) results in decreased serum levels of IGF-1, while acromegaly (growth hormone excess) results in elevated levels of IGF-1. IGF-1 measurements are also helpful in assessing nutritional status; levels are reduced in undernutrition and restored with a proper diet.
This test is used for the evaluation of growth disorders, growth hormone levels if it is more or less ,monitoring of human growth hormone treatment, Follow-up for individuals with acromegaly and gigantism. Deficiencies of IGF-1 can cause retardation of growth. IGF-1 which is similar to insulin structure can be measured to evaluate growth hormone level deficiencies such as hypopituitarism or excesses of growth hormone.
Reference Range(s)
Pediatric Male (ng/mL) Female (ng/mL)
1 Years 16-142 17-185
1-1.9 Years 16-134 16-175
2-2.9 Years 16-135 16-178
3-3.9 Years 30-155 38-214
4-4.9 Years 28-181 34-238
5-5.9 Years 31-214 37-272
6-6.9 Years 38-253 45-316
7-7.9 Years 48-298 58-367
8-8.9 Years 62-347 76-424
9-9.9 Years 80-398 99-483
10-10.9 Years 100-449 125-541
11-11.9 Years 123-497 152-593
12-12.9 Years 146-541 178-636
13-13.9 Years 168-576 200-664
14-14.9 Years 187-599 214-673
15-15.9 Years 201-609 218-659
16-16.9 Years 209-602 208-619
17-17.9 Years 207-576 185-551
Adult (ng/mL)
18-19.9 Years 108-548
20-24.9 Years 83-456
25-29.9 Years 63-373
30-39.9 Years 53-331
40-49.9 Years 52-328
50-59.9 Years 50-317
60-69.9 Years 41-279
70-79.9 Years 34-245
80 Years 34-246
Z-Score (Male) -2.0 - +2.0 SD
Z-Score (Female) -2.0 - +2.0 SD
