Description
Albumin and globulin are two types of protein in your body. The total protein test measures the total amount albumin and globulin in your body. It`s used as part of your routine health checkup. It may also be used if you have unexpected weight loss, fatigue, or the symptoms of a kidney or liver disease. The major proteins seen in the serum are albumin and globulin-the latter being primarily alpha 1 and alpha 2 globulin, beta globulin and gamma globulin. Albumin accounts for more than 50% of the total serum proteins.
The albumin to globulin (A/G) ratio has been used as an index of disease state, however, it is not a specific marker for disease because it does not indicate which specific proteins are altered. The normal A/G ratio is 0.8-2.0. The A/G ratio can be decreased in response to a low albumin or to elevated globulins. Total globulins may be increased in some chronic inflammatory diseases (TB, syphilis) multiple myeloma, collagen disease, and rheumatoid arthritis.
Decreased levels are seen in hepatic dysfunction, renal disease and various neoplasms. Protein, Total and Albumin test Includes Total Protein, Albumin, Globulin (calculated) and Albumin/Globulin Ratio (calculated).
